CARMMEN
The CARMMEN project aims to investigate the role of the muscle-specific protein Myopalladin (MYPN)—a key regulator of cardiac function—in heart regeneration, an area still largely unexplored despite evidence linking MYPN to muscle repair in human and animal studies.
To bridge this knowledge gap, CARMMEN will leverage the latest technological advances in the field of regenerative medicine, specifically of cardiac organoids (COs) for the first time in Cyprus, as an in vitro system simulating cardiac development and cardiomyogenesis, and zebrafish, as an in vivo model of cardiac regeneration.
Additionally, using CRISPR/Cas9 gene editing, we will recreate patient-specific MYPN mutations found in the biobak.cy database to model disease in COs and explore personalized treatment strategies. This work will offer new and more comprehensive insights into MYPN’s role in heart regeneration and contribute to targeted, patient-tailored therapies for cardiac diseases.
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