LifeEVA

The LifeEVA project aims to tackle the significant public health challenge of cardiovascular disease (CVD) by addressing early vascular ageing (EVA), characterized by increased arterial stiffness and reduced vascular compliance, particularly in young adults. The project seeks to develop and implement innovative, personalized lifestyle interventions targeting Cypriots aged 18-40 who are overweight or obese. Utilizing genetic data from biobank.cy, LifeEVA aims to understand the progression of EVA and reduce CVD risk through tailored dietary and physical activity counseling. 

The methodology involves a prospective, randomized, open-label, blinded endpoint trial over one year. Participants will be recruited from biobank.cy’s database, ensuring a robust sample. They will receive personalized interventions based on their genetic profile, including a hypocaloric diet, physical activity plan and taking into account other factors, such assmoking, sleep and anxiety etc. 

Anticipated results include significant reductions in vascular stiffness, improved cardiovascular health markers, and enhanced understanding of the interplay between genetics and lifestyle in EVA. The project’s impact extends to contributions to public health by reducing CVD prevalence and advancing the field of personalized preventive healthcare. LifeEVA is positioned to make significant contributions to cardiovascular research, promote innovation, and enhance the scientific and public health landscape in Cyprus. 

 

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Project :

 LIFEstyle Randomised Intervention for hEalthy Vascular Ageing – A multifactorial assessment of vascular ageing among Cypriots in early adulthood through biobank.cy 

 Coordinators: Yiota Veloudi (biobank.cy, UCY), Elena Loizidou (Bioinformatics Department, CING), Constantinos Deltas (biobank.cy, UCY) 

Other team members: Alexis Kyriacou (biobank.cy, UCY); Panagiotis Bargiotas (Medical School, UCY); Anastasia Antoniadou (Medical School, UCY); Marios Ioannides (Cardiology Department, Nicosia General Hospital, SHSO); Anastasios Bagourdis (Medical School, UNIC); Konstantina Dipla (AUTH); Andreas Zafeiridis (AUTH); Eva Karaglani (HUA); Maria Kafyra (HUA); Areti Traintafyllou (AUTH); Yiannis Mannios (HUA); Georgios Dedousis (HUA)