The animal model with the name Danio rerio, also known as zebrafish because of its zebra-like linings, is an attractive model for studying genetic diseases and discovering new knowledge regarding mechanisms of disease development. In collaboration with Dr Nicholas Dietis at the UCY Medical School and Dr Demetris Beis at the Biomedical Research Foundation Academy of Athens, we established new colonies of fish with the aim to create genetically modified animals for our experimentation. Specifically, we are interested in introducing to the zebrafish genetic variants we identify in patients with heart or kidney conditions and following the potential development of a disease phenotype. This is going to enable us to reach firm conclusions about the pathogenicity of variants of uncertain significance we find when diagnosing patients. Also, the same or similar models will allows us to ask more fundamental questions regarding the development of diseased animals under experimental conditions and even attempt therapeutic approaches.